产品货号：
Z11704
中文名称：
ATR抗体
英文名称：
Anti-ATR Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ATR Antibody |
| 指标别名 | ATR;FRAP related protein 1;FRP1;MEC1;SCKL;SCKL1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB |
| 基因名称 | ATR |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human ATR protein. |
| 计算分子量 | 301kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This product was affinity purified from monospecific antiserum by immunoaffinity chromatography.This antibody is specific for human ATR protein.A BLAST analysis was used to suggest cross-reactivity with ATR from human,mouse,rat,monkey,dog,fish and Xenopus sources based on a 100% homology with the immunizing sequence.?Cross-reactivity with ATR from other sources has not been determined. |
| 浓度 | 1.28mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidyl-inositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle.ATR activates checkpoint signaling upon genotoxic stresses,such as ionizing radiation (IR),ultraviolet light (UV),or DNA replication stalling,thereby acting as a DNA damage sensor.ATR is a member of the DNA-PK kinase family and is closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity.Chromosomal remodeling proteins have also been reported to associate with ATR complexes,including histone deacetylases (HDAC1,HDAC2 and CHD4).?ATR is known to phosphorylate BRCA1,CHEK1,MCM2,RAD17,RPA2,SMC1 and TP53/p53 which collectively inhibit DNA replication and mitosis and promote DNA repair,recombination and apoptosis.ATR is a nuclear protein,but can also be found in PML nuclear bodies in certain cell types.ATR is recruited to chromatin during S-phase and redistributes to discrete nuclear foci upon DNA damage,hypoxia or replication fork stalling. |
| Uniprot ID | Q13535 |
| 基因名全称 | Serine/threonine-protein kinase ATR |
| 推荐稀释比 | ELISA:1:15,000 - 1:70,000 WB:1:1,000 - 1:5,000 |
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